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jeudi 19 novembre 2009, 14h00, salle du conseil de l’UFR, attention, horaire et lieu exceptionel

Information processing in small gene regulatory networks and cascades

Aleksandra Walczak (Princeton Center for Theoretical Science)

par Pierre Pujol - 19 novembre 2009

Many of the biological networks inside cells can be thought of as transmitting information from the inputs (e.g., the concentrations of transcription factors or other signaling molecules) to their outputs (e.g., the expression levels of various genes). On the molecular level, the relatively small concentrations of the relevant molecules and the intrinsic randomness of chemical reactions provide sources of noise that set physical limits on this information transmission. Given these limits, not all networks perform equally well, and maximizing information transmission provides a optimization principle from which we might hope to derive the properties of real regulatory networks. I will discuss the properties of specific small networks that can transmit the maximum information. Concretely, I will show how the form of molecular noise drives predictions not just of the qualitative network topology but also the quantitative parameters for the input/output relations at the nodes of the network. In an attempt to link these general theoretical considerations to real biological systems, I will illustrate the predictions on the example of transmission of positional information in the early development of the fly embryo. Lastly, I will discuss different approaches of how a stochastic molecular level description can be successfully expanded to larger regulatory systems.